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TiUnite osseointegration linked to gene expression changes

The higher bone-to-implant contact of TiUnite vs. machined implants is associated with upregulation of molecular determinants of bone remodeling and regeneration.

An important discovery in osseointegration1: Histological and morphological changes in hard tissues surrounding TiUnite implants are correlated with gene expression changes of three important regulators of both bone remodeling and regeneration.

The animal study revealed that the molecular pathway involved in osseointegration was significantly more upregulated for TiUnite than with machined implants. At the bone-implant interface, the TiUnite surface shows more mineralized bone, higher bone-to-implant contact, and fewer points of separation of bone from implant during sample preparation, suggesting stronger implant retention by the bone. Interestingly, these differences are mirrored by changes in expression of genes involved in the osseointegration process. Specifically, the ratio of RANKL to OPG—the two competing RANK ligands—was significantly different around the two types of implants at 1, 3, 6, and 14, but not 28 days post implantation.

This suggests that the surface properties of TiUnite “rapidly stimulate bone formation and remodeling at the bone-implant interface” and “promote osseointegration.”